Transcriptomics

Dataset Information

18

Global transcriptomic profiling of oxygen-glucose deprivation (OGD)-mediated neuronal injury


ABSTRACT: Oxygen-glucose deprivation (OGD) is a cellular phenomenon consistently observed upon occurrence of ischemic stroke which eventually results in neuronal death. Neuronal cell death after ischemia takes place via two distinct processes, necrosis and apoptosis. Apoptosis, programmed cell death, is denoted by chromatin condensation, nuclear blebbing, cellular shrinkage, and DNA fragmentation. Unlike apoptosis, cellular swelling and lysis is suggestive of necrosis. However, these two processes are related not only to the severity but also to the duration of ischemia. Overall design: Microarray analysis was carried out using 20 Illumina mouse Ref8V1.1 genechip arrays. The assignment of the arrays was as follows: Controls (n=5); exposure to OGD for 10min, 5h, 8h, 15h and 24 h (n=3 respectively).

INSTRUMENT(S): Illumina mouseRef-8 v1.1 expression beadchip

ORGANISM(S): Mus musculus  

SUBMITTER: Minghui Jessica Chen  

PROVIDER: GSE23158 | GEO |

SECONDARY ACCESSION(S): PRJNA131563

REPOSITORIES: GEO

altmetric image

Publications

Sorry, this publication's infomation has not been loaded in the Indexer, please go directly to PUBMED or Altmetric.

Similar Datasets

2013-12-31 | E-GEOD-23158 | ArrayExpress
| GSE22993 | GEO
2013-12-31 | E-GEOD-22993 | ArrayExpress
2005-01-01 | MODEL1107050000 | BioModels Database
2013-12-31 | E-GEOD-23155 | ArrayExpress
| GSE23155 | GEO
2010-08-28 | E-GEOD-23847 | ArrayExpress
2005-01-01 | MODEL0912180000 | BioModels Database
2010-08-28 | GSE23847 | GEO
2009-04-22 | GSE15156 | GEO