TOX2 coordinates with TET2 to positively regulate central memory differentiation in human CAR T cells

ABSTRACT: To investigate the effects of TOX and TOX2 on memory T cell differentiation in human CAR T cells, we used shRNA to knock down TOX2 or TOX, or overexpress FLAG-TOX2. We then performed gene expression profiling analysis using RNAseq, plus examined the binding of TOX2 to chromatin using ChIPseq.

ORGANISM(S): Homo sapiens

PROVIDER: GSE231620 | GEO | 2023/07/24

REPOSITORIES: GEO