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A SCAN-box containing KRAB-ZFP maintains DNA methylation and inhibits gene expression

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE231898 | GEO | 2025/05/01

REPOSITORIES: GEO

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A SCAN-box containing KRAB-ZFP maintains DNA methylation and inhibits gene expression [RRBS]

Project description:DNA methylation is one of the most characteristic epigenetic modifications. In mammals, it is involved in a variety of biological processes, including transposable element silencing, gene expression regulation, genomic imprinting, and X chromosome inactivation. Here, through a medium-scale analysis of CpG islands loci coupled with ChIP-seq of Krüppel associated box zinc finger proteins (KRAB-ZFPs), we identified a murine ZFP, ZFP202, that bind to methylated CpG loci. We found that ZFP202 not only maintain CpG loci methylation, but also inhibit downstream gene expression in specific tissues. Disruption of ZFP202 in mouse led to genes upregulation in testis and placenta. Thus, our research identified a novel transcription factor that binding to methylated DNA and maintaining DNA methylation and promoting gene inhibition.

2025-05-01 | GSE231896 | GEO

A SCAN-box containing KRAB-ZFP maintains DNA methylation and inhibits gene expression [MeDIP-seq]

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A SCAN-box containing KRAB-ZFP maintains DNA methylation and inhibits gene expression [ChIP-seq]

2025-05-01 | GSE231892 | GEO

A SCAN-box containing KRAB-ZFP maintains DNA methylation and inhibits gene expression [RNA-seq]

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A SCAN-box containing KRAB-ZFP maintains DNA methylation and inhibits gene expression

Project description:A SCAN-box containing KRAB-ZFP maintains DNA methylation and inhibits gene expression

| PRJNA970197 | ENA

A SCAN-box containing KRAB-ZFP maintains DNA methylation and inhibits gene expression [RRBS]

Project description:A SCAN-box containing KRAB-ZFP maintains DNA methylation and inhibits gene expression [RRBS]

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A SCAN-box containing KRAB-ZFP maintains DNA methylation and inhibits gene expression [ChIP-seq]

Project description:A SCAN-box containing KRAB-ZFP maintains DNA methylation and inhibits gene expression [ChIP-seq]

| PRJNA970191 | ENA

A SCAN-box containing KRAB-ZFP maintains DNA methylation and inhibits gene expression [MeDIP-seq]

Project description:A SCAN-box containing KRAB-ZFP maintains DNA methylation and inhibits gene expression [MeDIP-seq]

| PRJNA970201 | ENA

A SCAN-box containing KRAB-ZFP maintains DNA methylation and inhibits gene expression [RNA-seq]

Project description:A SCAN-box containing KRAB-ZFP maintains DNA methylation and inhibits gene expression [RNA-seq]

| PRJNA970204 | ENA

Potential role of KRAB-ZFP binding and transcriptional states on DNA methylation of retroelements in human male germ cells.

Project description:DNA methylation, repressive histone modifications, and PIWI-interacting RNAs are essential for controlling retroelement silencing in mammalian germ lines. Dysregulation of retroelement silencing is associated with male sterility. Although retroelement silencing mechanisms have been extensively studied in mouse germ cells, little progress has been made in humans. Here, we show that the Krüppel-associated box domain zinc finger proteins are associated with DNA methylation of retroelements in human primordial germ cells. Further, we show that the hominoid-specific retroelement SINE-VNTR-Alus (SVA) is subjected to transcription-directed de novo DNA methylation during human spermatogenesis. The degree of de novo DNA methylation in SVAs varies among human individuals, which confers significant inter-individual epigenetic variation in sperm. Collectively, our results highlight potential molecular mechanisms for the regulation of retroelements in human male germ cells.

| S-EPMC8967385 | biostudies-literature

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