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Single cell gene expression analysis of aP2-Cre and Cdh5-Cre tdTomato labeled cells from multiple muscle [scRNA-seq]

ABSTRACT: Comparison of aP2-Cre and Cdh5-Cre tdTomato labaled cells from hindlimb and SCM muscles shows they mark the same endothelial cell populations

ORGANISM(S): Mus musculus

PROVIDER: GSE231918 | GEO | 2025/09/22

REPOSITORIES: GEO

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Low-input unstranded RNA sequencing on FACS isolated tdTomato positive cells from the sternocleidomastoid muscles of aP2-Cre;R26tdTomato and Cdh5-Cre;R26tdTomato animals

Project description:Gene expression of tdTomato positive FACS isolated sternocleidomastoid msucles from aP2-Cre;R26tdTomato and Cdh5-Cre;R26tdTomato animals for ssGSEA analysis

2025-09-22 | GSE302641 | GEO

single cell gene expression analysis of aP2-Cre and Cdh5-Cre tdTomato labeled cells from multiple muscle [scRNA-seq]

Project description:single cell gene expression analysis of aP2-Cre and Cdh5-Cre tdTomato labeled cells from multiple muscle [scRNA-seq]

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Low-input unstranded RNA sequencing on FACS isolated tdTomato positive cells from the sternocleidomastoid muscles of aP2-Cre R26tdTomato and Cdh5-Cre R26tdTomato animals

Project description:Low-input unstranded RNA sequencing on FACS isolated tdTomato positive cells from the sternocleidomastoid muscles of aP2-Cre R26tdTomato and Cdh5-Cre R26tdTomato animals

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Total stranded RNA sequencing on bulk tumor or FACS isolated tumor cells from known rhabdomyosarcoma models

Project description:Comparision of aP2-Cre, Myog-Cre and Cdh5-Cre SmoM2 driven tumors shows that Cdh5-Cre tumors express muscle markers but have unique gene expression profiles; Comparision of aP2-Cre SmoM2/tdTomato tumor cells and Cdh5-Cre SmoM2/tdTomato tumor cells isolated by FACS for CD31-/tdTomato+ cells reveals that Cdh5-Cre tumors are not rhabdomyosarcoma

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Low-input unstranded RNA sequencing on bulk tumor or FACS isolated tumor cells from known rhabdomyosarcoma models [Low-input_BulkRNAseq]

Project description:Comparision of aP2-Cre, Myog-Cre and Cdh5-Cre SmoM2 driven tumors shows that Cdh5-Cre tumors express muscle markers but have unique gene expression profiles Comparision of aP2-Cre SmoM2/tdTomato tumor cells and Cdh5-Cre SmoM2/tdTomato tumor cells isolated by FACS for CD31-/tdTomato+ cells reveals that Cdh5-Cre tumors are not rhabdomyosarcoma

2025-09-22 | GSE231917 | GEO

Total stranded RNA sequencing on bulk tumor or FACS isolated tumor cells from known rhabdomyosarcoma models [Total-Stranded_RNAseq]

Project description:Comparision of aP2-Cre, Myog-Cre and Cdh5-Cre SmoM2 driven tumors shows that Cdh5-Cre tumors express muscle markers but have unique gene expression profiles Comparision of aP2-Cre SmoM2/tdTomato tumor cells and Cdh5-Cre SmoM2/tdTomato tumor cells isolated by FACS for CD31-/tdTomato+ cells reveals that Cdh5-Cre tumors are not rhabdomyosarcoma

2025-09-22 | GSE231916 | GEO

Vascular tumor spectrum in aP2-Cre mice

Project description:Vascular tumor spectrum in aP2-Cre mice

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Gene expression profile of HSCs from Angptl2fl/fl or Cdh5-Cre;Angptl2fl/fl mice

Project description:To identify the intracellular targets of endothelial cell-specific ANGPTL2 that control HSC stemness, HSCs from Angptl2fl/fl or Cdh5-Cre;Angptl2fl/fl were sorted, followed by the extraction of total RNA and subjected to the RNA-sequencing.

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Vascular tumor spectrum in aP2-Cre mice

Project description:The combined activation of KrasG12D and loss of Cdkn2a leads to aggressive angiosarcomas in aP2-Cre mice. Whereas, the conditional deletion of Tsc1 leads to vascular tumor formation that mimic human kaposiform hemangioendotheliomas. We used Affymetrix microarrays to compare angiosarcoma tumors with the combined activation of KrasG12D and loss of Cdkn2a and the conditional deletion of Tsc1

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Utility of LysM-cre and Cdh5-cre Driver Mice in Retinal and Brain Research: An Imaging Study Using tdTomato Reporter Mouse.

Project description:PurposeThe lysozyme 2 (Lyz2 or LysM) cre mouse is extensively used to achieve genetic manipulation in myeloid cells and it has been widely employed in retinal research. However, LysM has been recently described to be expressed in brain neurons and there is a debate on whether it is also expressed by resident microglia in addition to infiltrating macrophages.MethodsWe examined LysM-cre recombination in retinal tissue using a LysM-cre/tdTomato reporter mouse together with immunolabeling for several retinal cell markers. We further compared LysM-cre tdTomato recombination with that of Cdh5-cre driver, which is expressed in both endothelial and hematopoietic cells.ResultsLysM-cre was strongly expressed in most microglia/resident macrophages in neonatal retinas (P8) and to a lesser extent in microglia of adult retinas. In addition, there was some neuronal recombination (8 %) of LysM-cre specifically in adult retinal ganglion cells and amacrine cells. After retinal ischemia-reperfusion injury, LysM-cre was strongly expressed in microglia/infiltrating macrophages. Cdh5-cre was expressed in endothelial and myeloid cells of P8 pups retinas. Unexpectedly, Cdh5 showed additional expression in adult mouse retinal ganglion cells and brain neurons.ConclusionsLysM-cre is expressed in macrophages and a subset of microglia together with a small but significant recombination of LysM-cre in the retinal neurons of adult mice. Cdh5 also showed some neuronal expression in both retina and brain of adult mice. These findings should be taken into consideration when interpreting results from central nervous system research using LysM-cre and Cdh5-cre mice.

| S-EPMC7405957 | biostudies-literature

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