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CITE-seq of LSK cells from aged mice after long-term iron chelator regimen

ABSTRACT: We found that iron chelation restored functional defects in aged HSC, including engraftment potential and platelet bias. To gain molecular insights into iron-dependent mechanism for sustaining HSC identity during aging, we performed Cellular Indexing of Transcriptomes and Epitopes by Sequencing (CITE-seq) with lineage (Lin)− Sca-1+ cKit+ (LSK) cells isolated from aged mice after long-term regimens with iron chelator Deferoxamine or vehicle control.

ORGANISM(S): Mus musculus

PROVIDER: GSE232022 | GEO | 2024/05/02

REPOSITORIES: GEO

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