Single-cell mRNA sequencing and TCR sequencing of CD4+ T cells in a mouse model of cutaneos B16 melanoma

ABSTRACT: This study sought to identify transcriptional states of CD4+ T cells from melanoma-challenged skin, primary tumours and tumour-draining lymph nodes. TCR sequencing was performed to identify expanded clonotypes to infer tumour-antigen specificity. This study identified heterogeneous populations of melanoma-specific CD4+ T cells that are distinct in the different anatomical locations.

ORGANISM(S): Mus musculus

PROVIDER: GSE232063 | GEO | 2023/11/21

REPOSITORIES: GEO