Unknown

Dataset Information

37

CpG islands Methylation Profiling by DMH in Epithelial Ovarian Cancer: Screening Set


ABSTRACT: We have systematically profiled DNA methylation at promoter CpG islands (CGIs) in ovarian cancer. Epithelial ovarian tumours, excluding mucinous and clear cell cancers, prospectively collected through a cohort study, were analyzed by differential methylation hybridization (DMH) (Nouzova M et al, 2004) in duplicates. The loci targeted by the custom-designed microarray are the promoter CpG islands (Gardiner-Garden and Frommer, 1987) of the genes involved in the Wnt, p53, AKT/mTOR, BRCA1/2 and Redox pathways, DNA repair (HR, NHEJ and MMR), FA family and IgLON family. Overall design: 111 ovarian tumor samples were assayed by DMH in duplicates. McrBC digested (Cy5) and undigested (Cy3) samples were competitively hybridized on the Agilent custom-designed microarrays 8x15k.

INSTRUMENT(S): Agilent custom-designed CpG island 60mer microarray 8x15k

ORGANISM(S): Homo sapiens  

SUBMITTER: Wei Dai  

PROVIDER: GSE23240 | GEO | 2011-06-01

SECONDARY ACCESSION(S): PRJNA131437

REPOSITORIES: GEO

Similar Datasets

2011-06-01 | E-GEOD-23240 | ArrayExpress
2006-11-03 | E-MEXP-881 | ArrayExpress
| PRJNA131437 | ENA
2009-04-28 | GSE15747 | GEO
2010-05-19 | E-GEOD-15747 | ArrayExpress
2009-04-28 | GSE15746 | GEO
2009-04-28 | E-GEOD-15746 | ArrayExpress
2006-10-31 | GSE5326 | GEO
| PRJNA156917 | ENA
| GSE94913 | GEO