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Effect of Flavivirus infections (Kunjin, Zika, Yellow Fever) on gene expression and alternative splicing in U87 cells.

ABSTRACT: As obligate intracellular parasites, viruses rely heavily on their host cells for their replication, and therefore dysregulate several cellular processes for their benefit. In return, host cells activate multiple signaling pathways to limit viral replication and eradicate viruses. The present study explores the complex interplay between viruses and their host cells through next generation RNA sequencing. The coding transcriptome of human brain-derived U87 cells infected with Kunjin virus, Zika virus, or Yellow Fever virus were compared to the transcriptome of mock-infected cells. Changes in the abundance of several hundred mRNAs were found in each infection. Moreover, the alternative splicing of hundreds of mRNAs was found to be modulated upon viral infection.

ORGANISM(S): Homo sapiens

PROVIDER: GSE232504 | GEO | 2023/06/28

REPOSITORIES: GEO

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