Itaconate enhances oncolytic virotherapy via multitarget inhibition of antiviral and inflammatory pathways

ABSTRACT: 4 octyl itaconate (4-OI) is a known anti-inflammatory chemical that activates Nrf2 signaling. Here, we are exploring the capacities of 4-OI to promote the spread of oncolytic Vesicular Stomatitis Virus (VSVd51M) in pLenti control kidney adenocarcinoma 786-O cell line and in Nrf2 knock out 786-O.

ORGANISM(S): Homo sapiens

PROVIDER: GSE232509 | GEO | 2023/06/15

REPOSITORIES: GEO