TOPBP1 Shapes XY Silencing Dynamics during Meiosis to Ensure Male Fertility

ABSTRACT: TOPBP1 and other DNA damage response proteins play an important role in meiotic sex chromosome inactivation. We investigate a mutant mouse with a mutation in the BRCT5 domain of TOPBP1 and use single-cell RNA-seq to investigate the effect of the mutation on XY silencing.

ORGANISM(S): Mus musculus

PROVIDER: GSE232588 | GEO | 2024/02/09

REPOSITORIES: GEO