Single-cell multi-omic detection of DNA methylation and histone modifications reconstructs the dynamics of epigenetic maintenance

ABSTRACT: DNA methylation and histone modifications encode epigenetic information. Recently, major progress was made to measure either mark at single-cell resolution. However, a method for simultaneous detection is lacking, preventing study of their interactions in complex systems. To bridge this gap, we developed scEpi2-seq. This technique provides single-molecule and single-cell readout of histone modifications and DNA methylation and reveals how DNA methylation maintenance is influenced by the local chromatin context.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE232637 | GEO | 2025/08/21

REPOSITORIES: GEO