Single-cell transcriptomic profling of the aging mouse choroid plexus

ABSTRACT: The blood-cerebrospinal fluid (B-CSF) barrier in the choroid plexus (CP) consists of tight junctions between CP epithelial cells. It is critical to maintaining the environmental homeostasis of the central nervous system and is associated with age-related disorders, such as neurodegenerative diseases. Nevertheless, its ageing is poorly understood. This study collects CP from both young and aged mice for single-cell sequencing, aiming at elucidating the molecular mechanisms driving the age-dependent degeneration of the B-CSF barrier in CP.

ORGANISM(S): Mus musculus

PROVIDER: GSE232782 | GEO | 2025/01/13

REPOSITORIES: GEO