Spatial Multimodal Analysis: MALDI-MSI and Spatial Transcriptomics within the same tissue section

ABSTRACT: We present a spatial omics approach that merges and expands the capabilities of independently performedin situassays on a single tissue section. Our spatial multimodal analysis combines histology, mass spectrometry imaging, and spatial transcriptomics to facilitate precise measurements of mRNA transcripts and low-molecular weight metabolites across tissue regions. We demonstrate the potential of our method using murine and human brain samples in the context of dopamine and Parkinson’s disease.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE232910 | GEO | 2023/05/21

REPOSITORIES: GEO