Chemical induction of hepatocyte revitalization in mouse hepatocytes [RNA-seq 1]

ABSTRACT: We then compared whole transcriptome bulk RNA-seq data of dHeps isolated from CCl4-injured mice and treated with either 5C, 3C, or DMSO. The expression of hepatocyte-enriched TFs and hepatocyte functional genes was upregulated in both the 5C and 3C groups, while mesenchymal markers (Acta2, Mmp3), inflammatory-related genes (Cxcl10, Ecm1, Ccl6, and Cd68), and oxidative stress-related genes (Ncf2 and Ncf1), were down-regulated compared with their expression in the DMSO control group

ORGANISM(S): Mus musculus

PROVIDER: GSE233081 | GEO | 2023/11/21

REPOSITORIES: GEO