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Novel XBP1s-independent function of IRE1 RNase in HIF-1a-mediated glycolysis upregulation in human macrophages

ABSTRACT: We investigated the immunometabolic reprogramming in SFA-treated human macrophages. As expected, RNA sequencing highlighted a pro-inflammatory profile but also metabolic signatures including glycolysis and hypoxia as well as a strong unfolded protein response.

ORGANISM(S): Homo sapiens

PROVIDER: GSE233446 | GEO | 2023/08/01

REPOSITORIES: GEO

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