Transcriptional profiling of primary human erythroblasts infected with Plasmodium falciparum

ABSTRACT: In malaria infection, Plasmodium spp. parasites accumulate in the bone marrow near sites of erythroid development. While it has been observed that Plasmodium falciparum infection of late-stage erythroblasts can delay terminal erythroid differentiation and enucleation, the mechanism(s) underlying this phenomenon are unknown. Here, we apply RNA-seq after fluorescence-activated cell sorting (FACS) of infected erythroblasts to identify transcriptional responses to direct and indirect interaction with P. falciparum.

ORGANISM(S): Homo sapiens Plasmodium falciparum

PROVIDER: GSE233739 | GEO | 2023/07/25

REPOSITORIES: GEO