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Redox-sensitive High-mobility group box-1 isoforms contribute to liver fibrosis progression and resolution in mice

ABSTRACT: To study role of different HMGB1 isoforms in liver fibrosis and resolution

ORGANISM(S): Mus musculus Rattus norvegicus

PROVIDER: GSE233751 | GEO | 2023/09/30

REPOSITORIES: GEO

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Redox-sensitive high-mobility group box-1 isoforms contribute to liver fibrosis progression and resolution in mice

Project description:Since oxidative stress plays a major role in liver fibrosis and induces post-translational modifications of proteins, we hypothesized that redox-sensitive HMGB1 isoforms contribute to liver fibrosis progression and resolution. This study is significant because a rise in [H] HMGB1 could flag 'patient at risk', the presence of [O] HMGB1 could suggest 'disease in progress or active scarring', while the appearance of [SO3] HMGB1 could point at 'resolution under way'. The latter could be used as a readout for response to pharmacological intervention with anti-fibrotic agents.

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