UBTF tandem duplication AMLs are sensitive to menin inhibition

ABSTRACT: To investigate the effect of Menin inhibitor on UBTF-TD harboring AML. We characterized UBTF-TD interaction with KMT2A and Menin in different leukemia models including KMT2A-r, transduced and normal cbCD34+ cells as well as in primary AML cells with UBTF-TD mutation. We also analized gene expression pattern upon treatment with Menin inhibitor.

ORGANISM(S): Homo sapiens

PROVIDER: GSE233810 | GEO | 2023/12/01

REPOSITORIES: GEO