Ketogenic diet induces p53-dependent cell senescence in multiple organs

ABSTRACT: Mice on two different ketogenic diets induce p53 and cellular senescence in multiple organs, including heart and kidney. This is mediated through inactivation of MDM2 by caspase-2 cleavage, leading to p53 accumulation and induction of p21. Ketogenic diet also induced pAMPK, suggesting that persistent activation leads to p53-dependent senescence.

ORGANISM(S): Mus musculus

PROVIDER: GSE233831 | GEO | 2024/04/12

REPOSITORIES: GEO