DNA methylation and expression profiling study for prostate cancer

ABSTRACT: Microarray-based DNA methylation and gene expression profiling was carried out using a panel of prostate cancer cell lines (LNCaP-FGC, DU-145, and PC-3) and the control normal prostate RWPE1 cell line. The identification of prostate cancer-specific methylation markers was based on the following criteria: a difference in DNA methylation level (β) of at least 0.5, and at least a 2-fold difference in expression level between cancer and control cells. Using highly stringent selection criteria, we identified novel hypermethylated genes whose expression was silenced in prostate cancer cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE23388 | GEO | 2011/07/25

SECONDARY ACCESSION(S): PRJNA131259

REPOSITORIES: GEO