Quantification of Bir1-dependent differential gene expression in swollen Aspergillus fumigatus conidia

ABSTRACT: This study aimed to understand the differences in gene expression when comparing Aspergillus fumigatus swollen conidia that overexpress an artifical Bir1 construct (strain published in Shlezinger et. al 2017) versus a parental control strain in RPMI + 0.5ug/mL voriconazole. The purpose of this experiment was to understand what basal expression differences may drive a decreased susceptibility to hydrogen peroxide upon subsequent treatment (not tested in this submission). The main results show that there is a significant upregulation of mitochondrial-related genes, included aconitate hydratase. These differences may account for increased susrvival upon cellular stressors in this strain background.

ORGANISM(S): Aspergillus fumigatus

PROVIDER: GSE233942 | GEO | 2023/10/10

REPOSITORIES: GEO