RNA sequencing analysis of IECs from WT and PIM1+/- mice

ABSTRACT: PIM1 is constitutively active and involved in various cellular processes, including cell survival, proliferation, and differentiation by phosphorylating a wide range of substrates. We investigated whether PIM1 is involved in the pathogenesis of ulcerative colitis (UC).We performed RNA sequencing analysis in intestinal epithelial cells (IECs) from PIM1-deficient mice and WT mice to study the molecular mechanisms through which PIM1 regulates goblet cell numbers.

ORGANISM(S): Mus musculus

PROVIDER: GSE234120 | GEO | 2024/07/30

REPOSITORIES: GEO