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Human stem cell-derived cardiomyocytes integrate into the heart of monkeys with surgically-created congenital-like cardiac defect

ABSTRACT: To investigate the transplantation of human induced pluripotent stem cell-derived cardiac lineage-cells into the heart of rhesus macaques with a surgical model of right ventricular pressure overload.

ORGANISM(S): Homo sapiens

PROVIDER: GSE234206 | GEO | 2023/06/30

REPOSITORIES: GEO

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IL15 in treatment of rhesus macaques

Project description:Rhesus macaques vaccinated by rhesus cytomegalovirus vectors expressing simian immunodeficiency virus proteins (RhCMV/SIV) activate gene expression signature associated with IL15. To examine the gene expression signature activated by IL15, we performed longitudinal examinations of rhesus macaques during IL15 treament.

2021-06-28 | GSE160577 | GEO

Dramatic effects of social behavior on gene regulation in rhesus macaques

Project description:This SuperSeries is composed of the following subset Series: GSE33090: Dramatic effects of social behavior on gene regulation in rhesus macaques [Individual_expression] GSE34127: Dramatic effects of social behavior on gene regulation in rhesus macaques [Cell type_expression] GSE34128: Dramatic effects of social behavior on gene regulation in rhesus macaques [Bisulfite_seq] Refer to individual Series

2012-02-01 | E-GEOD-34129 | biostudies-arrayexpress

Translational Insights from Cell-type variation across Amygdala Subnuclei in Rhesus Monkeys and Humans

Project description:Theories of amygdala function are central to our understanding of psychiatric and neurodevelopmental disorders. However, our limited knowledge of the molecular and cellular composition of the amygdala impedes translational research aimed at developing new treatments and interventions. Here, we use single-nucleus RNA-sequencing from multiple amygdala subnuclei in both humans (n=3, Male) and rhesus macaques (n=3, Male) to begin to bridge the gap between preclinical rodent models and human disorders. Our results reveal substantial heterogeneity between regions, even when restricted to inhibitory or excitatory neurons. Consistent with prior work, our data highlight the complexities of individual marker genes for uniquely targeting specific cell-types. Cross-species analyses suggest the rhesus monkey model to be well-suited to understanding the human amygdala, but also identify limitations. For example, we identified a cell-cluster in the ventral lateral nucleus (vLA) of the amygdala that is enriched in humans, relative to rhesus macaques. Additionally, we identify specific cell-clusters with relative enrichment of disorder-related genes. These analyses point to the human-enriched vLa cell-cluster as relevant to ASD, potentially highlighting a vulnerability to neurodevelopmental disorders that has emerged in recent primate evolution. Further, we identified a cluster of cells expressing markers for intercalated cells (ITCs) that is enriched for genes reported in human genome-wide association studies of neuroticism, anxiety disorders, and depressive disorders. Together, these data shed light on the composition of the amygdala and identify specific cell-types that can be prioritized in basic science research to better understand human psychopathology and guide the development of potential treatments

2024-04-05 | GSE262905 | GEO

Interhemispheric differences in gene expression of the cerebral cortex in humans and macaque monkeys

Project description:Handedness and language are two well-studied examples of asymmetrical brain function in humans. Approximately 90% of humans exhibit a right-hand preference, and the vast majority shows left-hemisphere dominance for language function. Although genetic models of human handedness and language have been proposed, the actual gene expression differences between cerebral hemispheres in humans remain to be fully defined. In the present study, gene expression profiles were examined in both hemispheres of three cortical regions involved in handedness and language in humans and their homologues in rhesus macaques: ventrolateral prefrontal cortex, posterior superior temporal cortex (STC), and primary motor cortex. Although the overall pattern of gene expression was very similar between hemispheres in both humans and macaques, weighted gene correlation network analysis revealed gene co-expression modules associated with hemisphere, which are different among the three cortical regions examined. Notably, a receptor-enriched gene module in STC was particularly associated with hemisphere and showed different expression levels between hemispheres only in humans.

2017-03-29 | GSE76644 | GEO

LFQ quantitative analysis of 6 rhesus macaques prefrontal cortex samples from Shanghai Ninth People's Hospital

Project description:Rhesus macaques that were exposed to sevoflurane on three occasions during the early postnatal period (days 7, 21, and 35) showed signs of anxiety and impaired visual recognition memory, according to previous studies. By using this animal model, we were able to study the changes in proteomics and RNA sequencing in the prefrontal cortex of rhesus macaques after sevoflurane anesthesia.Proteomics analysis of the brain found that the functions of different proteins expressed after sevoflurane exposure in rhesus macaques were mainly related to mitochondrial respiration.

2023-08-10 | PXD044509 | iProX

Candidate Vaccine Assessment in a pH1N1 Rhesus Macaque Challenge Model

Project description:A mixed-aerosol pH1N1 (Cal04) challenge of rhesus macaques was establised to serve as a pre-clinical model for the evaluation of candidate vaccines. After characterizing the clinical signs and immune responses associated with pH1N1 challenge in naïve rhesus macaques, a follow-up study assessing 2 candidate vaccines was performed.

2014-10-24 | GSE60009 | GEO

Oral mucosal response to SIV infection

Project description:The objectives of this study were to determine the molecular mechanisms of host response during transition from primary to chronic SIV infection in the oral mucosa of rhesus macaques Transcriptioinal profiles were determined for 2 rhesus macaques infected for 6 wk with SIVmac251 and compared to profiles of 3 uninfected healthy controls

2009-01-12 | E-GEOD-14351 | biostudies-arrayexpress

Dramatic effects of social behavior on gene regulation in rhesus macaques [Individual_expression]

Project description:Analysis of gene expression differences in relationship to dominance rank in female rhesus macaques. RNA obtained from isolated peripheral blood mononuclear cells from 49 adult female rhesus macaques of dominance ranks 1 (high) to 5 (low) across 10 social groups. Total 100 samples = (47 individuals X 2 replicates) + (2 individuals X 3 replicates)

2012-02-01 | E-GEOD-33090 | biostudies-arrayexpress

Dramatic effects of social behavior on gene regulation in rhesus macaques [Cell type_expression]

Project description:Analysis of gene expression differences in relationship to dominance rank in female rhesus macaques. RNA obtained from 4 cell populations (helper T cells, cytotoxic T cells, monocytes, and B cells) from isolated peripheral blood mononuclear cells sampled from 5 adult female rhesus macaques across 5 different social groups and 5 different dominance ranks [dominance ranks : 1 = high, 5 = low]

2012-02-01 | E-GEOD-34127 | biostudies-arrayexpress

Rhesus macaque model of hCoV-EMC respiratory infection

Project description:Microarray analysis of peripheral blood mononuclear cells (PBMCs), lungs, and lung lesions collected over the course of hCoV-EMC infection of 6 rhesus macaques. 6 rhesus macaques were infected intratracheally with hCoV-EMC. PBMCs were collected at days 0, 1, 3, and 6, and lungs were collected from serial sacrifices of 3 animals each at day 3 and day 6. Infection produced a mild-moderate, self-limiting respiratory infection, and was not lethal. We performed microarray analysis (using Agilent Rhesus arrays) on all lungs, lung lesions, and PBMCs collected for the study.

2013-08-29 | E-GEOD-44542 | biostudies-arrayexpress

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