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Effect of SARS-CoV-2 infection on breast cancer cell lines (24h)

ABSTRACT: COVID-19 pandemic, caused by SARS-CoV-2 virus, had significant consequences for individuals already dealing with various pathological conditions, including breast cancer. Emerging evidence suggests that SARS-CoV-2 infection may directly affect breast cancer cell biology, even though a deeper understanding of the virus's effects on tumor cells is still not completely achieved. The present study aimed at examining the molecular events taking place in three different breast cancer cell lines of distinct molecular subtypes upon SARS-CoV-2 virus infection. Specifically, MCF7, MDAMB231, and HCC1937 cell lines, representing luminal A, basal B/claudin low, and basal A molecular subtypes, respectively, were subjected to SARS-CoV-2 infection and gene expression profile analysis was conducted at 24 hours and 7 days post infection. Obtained data revealed that MCF7 cells exhibited the highest susceptibility to viral replication. Interestingly, genes upregulated by SARS-CoV-2 virus in all three cell lines were able to identify a subgroup of breast cancer patients characterized by poor prognosis. Given the ongoing spread of the SARS-CoV-2 virus within the population, it is crucial to gain a better comprehension of its direct impact on breast cancer and to assess the long-term consequences of COVID-19 on breast cancer outcomes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE234242 | GEO | 2024/06/12

REPOSITORIES: GEO

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