Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Activated stroma dictates response to gemcitabine in combination with nab-paclitaxel in pancreatic ductal adenocarcinoma patient derived xenografts (PDAC-PDX).

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE234259 | GEO | 2025/04/16

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Activated stroma dictates response to gemcitabine in combination with nab-paclitaxel in pancreatic ductal adenocarcinoma patient derived xenografts (PDAC-PDX) [murine Agilent microarray]

Project description:Transcription profiling of PDAC-PDX orthotopically engrafted in the pancreas of immunodeficient mice.

2025-04-16 | GSE234258 | GEO

Activated stroma dictates response to gemcitabine in combination with nab-paclitaxel in pancreatic ductal adenocarcinoma patient derived xenografts (PDAC-PDX) [human Agilent microarray]

Project description:Transcription profiling of PDAC-PDX orthotopically engrafted in the pancreas of immunodeficient mice.

2025-04-16 | GSE234257 | GEO

Activated stroma dictates response to gemcitabine in combination with nab-paclitaxel in pancreatic ductal adenocarcinoma patient derived xenografts (PDAC-PDX).

Project description:Activated stroma dictates response to gemcitabine in combination with nab-paclitaxel in pancreatic ductal adenocarcinoma patient derived xenografts (PDAC-PDX).

| PRJNA980635 | ENA

Activated stroma dictates response to gemcitabine in combination with nab-paclitaxel in pancreatic ductal adenocarcinoma patient derived xenografts (PDAC-PDX) [human Agilent microarray]

Project description:Activated stroma dictates response to gemcitabine in combination with nab-paclitaxel in pancreatic ductal adenocarcinoma patient derived xenografts (PDAC-PDX) [human Agilent microarray]

| PRJNA980641 | ENA

Activated stroma dictates response to gemcitabine in combination with nab-paclitaxel in pancreatic ductal adenocarcinoma patient derived xenografts (PDAC-PDX) [murine Agilent microarray]

| PRJNA980642 | ENA

Label-free proteomics quantification of pancreatic ductal adenocarcinoma patient-derived xenografts with treatment combining Gemcitabine and nab-Paclitaxel

Project description:Tumor-stroma interactions are critical in pancreatic ductal adenocarcinoma (PDAC) progression and therapeutics. Patient-derived xenograft (PDX) models faithfully recapitulate tumor-stroma interactions in PDAC, but conventional antibody-based immunoassay is largely inadequate to resolve or quantify tumor and stromal proteins. A species-deconvolved proteomics approach embedded in the ultra-high-resolution (UHR)-IonStar workflow can unambiguously quantify the proteins from tumor (human-derived) and stroma (mouse-derived) in PDX samples, enabling unbiased investigation of their proteomes with excellent quantitative reproducibility. With this strategy, 3 PDAC PDXs were analyzed. They were showed differential responses to treatment with Gemcitabine combined with nab-Paclitaxel (GEM+PTX), which is a first-line treatment regimen for PDAC. For each PDAC PDX, samples were collected after 24 hour and 192 hour with/without treatment, and each condition contained four biological replicates.

2023-07-05 | PXD042267 | Pride