Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression profile of either Dead neuron+/Fcrls+/CD11b+/Ly6C- or Dead neuron-/Fcrls+/CD11b+/Ly6C- microglia from the brain II

ABSTRACT: We used bulk RNA sequencing to investigate the molecular signature of phagocytic and non-phagocytic microglia affected by APOE isoform (APOE3-KI vs. APOE3-cKO vs. APOE4-KI vs. APOE4-cKO)

ORGANISM(S): Mus musculus

PROVIDER: GSE234350 | GEO | 2023/07/31

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Gene expression profile of either Dead neuron+/Fcrls+/CD11b+/Ly6C- or Dead neuron-/Fcrls+/CD11b+/Ly6C- microglia from the brain I

Project description:We used bulk RNA sequencing to investigate the molecular signature of phagocytic and non-phagocytic microglia affected by APOE isoform (APOE3-KI vs. APOE4-KI)

2023-07-31 | GSE234348 | GEO

Gene expression profile of Fcrls+/CD11b+/Ly6C- microglia from the brain II

Project description:We used bulk RNA sequencing to investigate the molecular signature of microglia affected by microglia-specific APOE isoform (APOE3 vs. APOE4) in both WT and P301S mice

2023-07-31 | GSE234391 | GEO

Gene expression profile of either Dead neuron+/Fcrls+/CD11b+/Ly6C- or Dead neuron-/Fcrls+/CD11b+/Ly6C- microglia from the brain

Project description:We used bulk RNA sequencing to investigate the molecular signature of both phagocytic microglia and non-phagocytic microglia affected by deletion of Itgb8 in microglia.

2023-07-31 | GSE234502 | GEO

Gene expression profile of Fcrls+/CD11b+/Ly6C- microglia from the brain I

Project description:We used bulk RNA sequencing to investigate the molecular signature of microglia affected by PU.1 inhibitor in APP/PS1:APOE4-KI mice.

2023-07-31 | GSE234383 | GEO

Gene expression profile of Dead neuron+/Fcrls+/CD11b+/Ly6C- microglia from the brain

Project description:We used bulk RNA sequencing to investigate the molecular signature of phagocytic microglia affected by deletion of Spi1 in microglia.

2023-07-31 | GSE234380 | GEO

Gene expression profile of Fcrls+/CD11b+/Ly6C- microglia from the brain III

Project description:We used bulk RNA sequencing to investigate the molecular signature of microglia isolated from Itgb8 cKO vs. Control mice.

2023-07-31 | GSE234496 | GEO

Gene expression profile of ACSA-2+/O1-/CD11b-/Cd45-/Olig4- astrocytes from the brain IV

Project description:We used bulk RNA sequencing to investigate the astrocytic signature isolated from dead-neuron-injected 8-month-old APOE4-cKO mice compared with APOE4-KI mice

2023-07-31 | GSE234480 | GEO

Gene expression profile of Fcrls+/CD11b+/Ly6C- microglia from the brain V

Project description:We used bulk RNA sequencing to investigate the molecular signature of microglia affected by deletion of microglial APOE4 in APP/PS1 mice.

2023-07-31 | GSE235630 | GEO

APOE4 cell-specific mechanisms underlying cerebrovascular disorder precede neuronal and synaptic dysfunction and cognitive deficits in mice

Project description:We performed single-nucleus RNA-sequencing of the cortex of APOE3 and APOE4 knock-in (KI)flox/flox mice to investigate the effects of human APOE4 gene on cell-specific signaling mechanisms at the BBB and in the brain.

2022-08-22 | GSE185063 | GEO

Differential gene expression in APOE3 and APOE4 gene targeted replacement mice

Project description:The aim of the study was to investigate hepatic gene expression profiles differentially regulated by the APOE genotype in gene targeted replacement mice. The APOE4 genotype is associated with increased mortality in the elderly and is an independent risk factor for age-dependent chronic diseases. However, little is known about the underlying mechanisms and molecular targets involved in the APOE4-risk association. As APOE is centrally involved in lipid and cholesterol metabolism and in large part is produced in the liver, we analyzed hepatic RNA profiles of APOE4- and APOE3-expressing mice. 2 groups of 5 animals with 1 liver extract per animal. Mice were homozygous for a human APOE3 or APOE4 gene targeted replacement of the endogenous mouse Apoe gene (B6.129P2-Apoetm2(APOE*3)Mae N8 or B6.129P2-Apoetm3(APOE*4)Mae N8, Taconic Transgenic ModelsM-bM-^DM-", http://www.taconic.com/wmspage.cfm?parm1=2542), purchased at the age of 6-8 weeks, strain C57BL/6, 3 months old at the performance of the microarray, 6 weeks on a high-fat diet containing 41% energy from milk fat and 2 g/kg cholesterol.

2012-12-15 | E-GEOD-42930 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data