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Gene expression profiling on 2D vs 3D iPSC colonies

ABSTRACT: In this study, we aimed to investigate the influence of the local mechanical cell niche on mechano-responsive signaling activities and germ layer specification by engineering a unique 3D semispherical colony of human-induced pluripotent stem cells (iPSCs). To achieve this, we utilized a combination of an electrospun nanofibrous substrate and PDMS microwells. Specifically, we compared the gene expression profiles of iPSCs cultured on a plastic plate with those cultured on a PCL nanofibrous substrate (19 kPa).

ORGANISM(S): Homo sapiens

PROVIDER: GSE234529 | GEO | 2023/06/13

REPOSITORIES: GEO

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Human endothelial cell microRNA expression in high and low stiffness [sRNA-seq]

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Matrix Elasticity Does Not Affect Replicative Senescence or DNA Methylation Patterns of Mesenchymal Stem Cells [gene expression profiling]

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2018-08-29 | PXD010910 | Pride

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