RNA-Seq analysis of Candida glabrata wild-type and Cgsnf2Δ strains in RPMI-grown or macrophage-internalized conditions at 2 h and 10 h post-infection.

ABSTRACT: The goal of the current study was to identify differentially-expressed genes upon CgSNF2 deletion, as well as, upon macrophage internalization in C. glabrata wild-type (wt) and Cgsnf2Δ strains. For this study, RNA samples were collected from RPMI-grown and macrophage-internalized cells of C. glabrata wild-type and Cgsnf2Δ strains at 2 h and 10 h post-infection. Comparative transcriptome analysis shows the differential regulation of 1419 genes in C. glabrata wild-type cells upon macrophage internalization, whereas the CgSNF2 deletion leads to altered regulation of 935 genes in C. glabrata wild-type cells.

ORGANISM(S): Nakaseomyces glabratus

PROVIDER: GSE234670 | GEO | 2024/04/16

REPOSITORIES: GEO