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The transcriptional regulatory landscape of LMO2 in tumor angiogenesis and breast cancer metastasis

ABSTRACT: To study the role of LMO2 in in human umbilical vein endothelial cells(Huvecs) and analyze the genes regualted by LMO2, we performed siRNA (3 replicates) of LMO2 and negative siRNA as control in Huvecs for deep sequencing. Further more, to research the regualatory mechanism of LMO2. We use Chromatin Immunoprecipitation sequencing (ChIP) to find the genes bound with LMO2. In this way, we confirm LMO2 activates genes through binding genes and promotes cancer related functions.

ORGANISM(S): Homo sapiens

PROVIDER: GSE235320 | GEO | 2026/06/20

REPOSITORIES: GEO

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