Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effect of Morc1 knock out on gonocyte chromatin and transcriptome [RNA-Seq 2]

ABSTRACT: To investigate the function of Morc1 to chromatin state during gonocyte stage when around 10,000 copies of transposons are deregulated.

ORGANISM(S): Mus musculus

PROVIDER: GSE235428 | GEO | 2024/02/05

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Effect of Morc1 knock out on gonocyte chromatin and transcriptome [ChIP-Seq]

Project description:To investigate the function of Morc1 to chromatin state during gonocyte stage when around 10,000 copies of transposons are deregulated.

2024-02-05 | GSE235426 | GEO

Effect of Morc1 knock out on gonocyte chromatin and transcriptome [ATAC-Seq]

Project description:To investigate the function of Morc1 to chromatin state during gonocyte stage when around 10,000 copies of transposons are deregulated.

2024-02-05 | GSE235425 | GEO

Effect of Morc1 knock out on gonocyte chromatin and transcriptome [RNA-Seq 1]

Project description:To investigate the function of Morc1 to chromatin state during gonocyte stage when around 10,000 copies of transposons are deregulated.

2024-02-05 | GSE235427 | GEO

MORC1 represses transposable elements in the mouse male germ line

Project description:The Microrchidia (Morc) family of GHKL ATPases are present in a wide variety of prokaryotic and eukaryotic organisms but are of largely unknown function. Genetic screens in Arabidopsis thaliana have identified Morc genes as important repressors of transposons and other DNA methylated and silent genes. MORC1 deficient mice were previously found to display male-specific germ cell loss and infertility. Here we show that MORC1 is responsible for transposon repression in the male germline in a pattern that is similar to that observed for germ cells deficient for the DNA methyltransferase homolog DNMT3L. Morc1 mutants show highly localized defects in the establishment of DNA methylation at specific classes of transposons, and this is associated with failed transposon silencing at these sites. Our results identify MORC1 as an important new regulator of the epigenetic landscape of male germ cells during the period of global de novo methylation. This data includes: 47 RNA-seq, 4 smRNA-seq, 6 BS-seq, and 2 ChIP-seq datasets

2014-12-12 | E-GEOD-63048 | biostudies-arrayexpress

MORC1 represses transposable elements in the mouse male germ line

2014-12-12 | GSE63048 | GEO

Effect of Morc1 knock out on gonocyte chromatin and transcriptome

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-02-05 | GSE235429 | GEO

Expression profile (nanoCAGE-seq), chromatin accessibility (ATAC-seq) profile, and histone modification profile (ChIP-seq for H3K4me3, H3K9me3, and H3K27me3) during the course of mouse gonocyte development

Project description:How de novo DNA methylation over heterochromatin is introduced in mouse gonocyte remains obscure. We performed nanoCAGE-seq, ChIP-seq for three major histone marks (H3K4me3, H3K9me3, H3K27me3), ATAC-seq, Hi-C during the course of mouse gonocyte development (E13.5, E17.5, E19.5, P2)

2019-08-29 | GSE121118 | GEO

Constitutive expression of activated NOTCH1 in fetal Sertoli cells dysregulates factors required for proper gonocyte maintenance and survival.

Project description:Genome-wide analysis of whole embryonic day 14.5 mouse testes constitutively expressing the activated intracellular domain of NOTCH1 in Sertoli cells. The goal of the study was to identify Sertoli cell expressed genes regulated by Notch signaling, which are critical to gonocyte maintenance and survival. The mouse model was generated by intercrossing anti-Müllerian hormone (Amh)-cre transgenic mice and RosaNICD transgenic mice. Testes were dissected free from mesonephroi and testis pairs from a single fetus were pooled to generate a single sample. Littermates not expressing Amh-cre were used as controls. Testes from one control and one overexpressor fetus per dam from three separate dams were used for analysis.

2013-02-08 | E-GEOD-37073 | biostudies-arrayexpress

TSG knock out in hiPSCs

Project description:We will perform RNAseq to evaluate the effects of the loss of a list of TSGs on the transcriptome.

| EGAS00001002262 | EGA

Constitutive expression of activated NOTCH1 in fetal Sertoli cells dysregulates factors required for proper gonocyte maintenance and survival.

2013-02-08 | GSE37073 | GEO