Genomics

Dataset Information

0

Profiles of gene expression in skeletal muscle in sheep from the middle gestation to postnatal stages


ABSTRACT: Texel and Ujumqin sheep show obvious differences in muscle and fat growth, so they are ideal models not only to understand the molecular mechanism in prenatal skeletal muscle development, but to identify the potential target genes of myostatin. To elucidate the phenotypic variation between the two sheep breeds and the dynamic characteristics of gene expression in skeletal muscle during the development, we examined the development of skeletal muscle in transcriptome-wide level at 70, 85,100,120 , 135 days post coitus (dpc),birth, 1 month and 2 month. Using the specialized and standardized sheep transcriptome-wide oligo DNA microarray (Agilent), we analyzed the transcriptomic profiles of longissmuss dorsi muscle from fetuses of Texel and Ujumqin sheep. We characterized dynamic transcriptome-wide profiles that accompany the prenatal skeletal muscle and fat development in Texel and Ujumqin sheep respectively, and compared the difference in profiles of gene expression between the two sheep breeds at the same developmental stage.Some potential myostatin target genes and other genes controlling the growth of skeletal muscle and adipose were identified for further examinations. Our findings not only contribute to understand the molecular mechanism of prenatal skeletal muscle development in large precocial species, but also provide some clues for human myopathy and obesity at prenatal stages. Moreover, we also can identify putative candidate genes for meat quality traits in farm animals.

ORGANISM(S): Ovis aries

PROVIDER: GSE23563 | GEO | 2010/12/20

SECONDARY ACCESSION(S): PRJNA131795

REPOSITORIES: GEO

Similar Datasets

| E-GEOD-23563 | biostudies-arrayexpress
2020-05-29 | GSE130622 | GEO
2007-08-10 | GSE5494 | GEO
| E-GEOD-5494 | biostudies-arrayexpress
2017-08-17 | PXD005899 | Pride
2022-07-08 | GSE190327 | GEO
2022-07-08 | GSE190326 | GEO
| E-GEOD-30344 | biostudies-arrayexpress
| E-GEOD-30343 | biostudies-arrayexpress
2019-12-31 | GSE134519 | GEO