Transcriptional response to Notch activation in SVG-A cells

ABSTRACT: SVG-A cells are immortalized fetal astrocytes that respond to Notch signaling. We characterized the transcriptional response to Notch activation in this cell line by performing RNA-seq on cells grown on tissue culture dishes coated with JAGGED1, a Notch ligand. Differential gene expression analysis shows induction of both canonical Notch responsive genes, as well as cell-type specific Notch responsive genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE235637 | GEO | 2024/02/28

REPOSITORIES: GEO