Off-target effect of CWG-cPIP on gene expression of human fibroblasts

ABSTRACT: CWG-cPIP targets CAG/CTG (CWG) triplet repeat DNA to inhibit the transcription in a repeat length-dependent manner. To investigate off-target effects of CWG-cPIP on gene expression in cells, CWG-cPIP (1 μM) was treated to human fibroblasts. RNA sequencing analysis was performed using vehicle- or CWG-cPIP-treated human fibroblasts 7 days later, mixing with ERCC RNA spike-in controls.

ORGANISM(S): Homo sapiens

PROVIDER: GSE235810 | GEO | 2023/10/11

REPOSITORIES: GEO