Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The Identification of Genetic Factors Influencing Susceptibility to Staphylococcus aureus Infection in mice susceptible and resistant to S. aureus infection

ABSTRACT: It has been shown that inbred strains of mice exhibit variable susceptibility to S. aureus infection, but the specific genes responsible for this differential phenotype are unknown. Using ISHM to identify genomic regions associated with the phenotypes, we considered genes within those interval to be candidate genes and used the gene expression patterns of the genes contained in the region to determine whether the genes are differentially expressed between the 2 phenotypically different groups of mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE23584 | GEO | 2011/12/31

SECONDARY ACCESSION(S): PRJNA131837

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

The Identification of Genetic Factors Influencing Susceptibility to Staphylococcus aureus Infection in mice susceptible and resistant to S. aureus infection

Project description:It has been shown that inbred strains of mice exhibit variable susceptibility to S. aureus infection, but the specific genes responsible for this differential phenotype are unknown. Using ISHM to identify genomic regions associated with the phenotypes, we considered genes within those interval to be candidate genes and used the gene expression patterns of the genes contained in the region to determine whether the genes are differentially expressed between the 2 phenotypically different groups of mice. To identify genes differentially expressed between mice susceptible and resistant to S. aureus infection that could contribute to host susceptibility to S. aureus infection, we compared the gene expression profiles between 2 groups of mice where 3 were susceptible (A/J, BALBcBy/J, AKR/J) and resistant (C57BL/J, C3H/HeJ, NOD/ShiLtJ) to S. aureus. The susceptible group had high bacterial count values in the kidney while the resistant group had low values.

2011-12-31 | E-GEOD-23584 | biostudies-arrayexpress

Continued in vitro cefazolin susceptibility in methicillin-susceptible Staphylococcus aureus.

Project description: Not available

| S-EPMC5819674 | biostudies-literature

Genes Influencing Susceptibility to Infection and Malnutrition

Project description:Genes Influencing Susceptibility to Infection and Malnutrition

| PRJNA416029 | ENA

Genes Influencing Susceptibility to Infection and Malnutrition

Project description:Genes Influencing Susceptibility to Infection and Malnutrition

| PRJNA416030 | ENA

Methicillin-Susceptible, Vancomycin-Resistant Staphylococcus aureus, Brazil.

Project description: Not available

| S-EPMC4593430 | biostudies-literature

Genetic Determinants for Susceptibility to Staphylococcus aureus Infection in A/J and C57BL/6J

Project description:Although it has recently been shown that A/J mice are highly susceptible to Staphylococcus aureus sepsis as compared to C57BL/6J, the specific genes responsible for this differential phenotype are unknown. Using chromosome substitution strains (CSS), we found that factors on chromosomes (chr) 8, 11, and 18 are responsible for susceptibility to S. aureus sepsis in A/J mice. F1 mice from C57BL/6J X CSS8 cross (C8A) and C57BL/6J X CSS18 (C18A) were also susceptible to S. aureus (median survival < 48 h), whereas F1 mice from C57BL/6J X CSS11 cross (C11A) were resistant (median survival > 120 h) to S. aureus. Bacterial loads in the kidney were consistent with F1 median survivals, with higher bacterial counts in susceptible mice. No sexlinked associations with susceptibility were noted in F1 intercrosses. Using whole genome transcription profiling, we identified a total of 192 genes on chromosomes 8, 11, and 18 which are differentially expressed between A/J and C57BL/6J in the setting of S. aureus infection. Of these, 28 genes had Gene Ontology annotations indicating a potential immune response function. These 28 genes are associated with susceptibility to S. aureus in A/J mice, and are potential determinants of susceptibility to S. aureus infection in humans.

2010-08-01 | GSE19668 | GEO

Genetic Determinants for Susceptibility to Staphylococcus aureus Infection in A/J and C57BL/6J

2010-08-01 | E-GEOD-19668 | biostudies-arrayexpress

Susceptibility of Methicillin-Resistant and -Susceptible Staphylococcus aureus Isolates of Various Clonal Lineages from Germany to Eight Biocides.

Project description: Not available

| S-EPMC6007098 | biostudies-literature

Staphylococcus aureus infection dynamics.

Project description: Not available

| S-EPMC6019756 | biostudies-literature

Surveillance for Colonization, Transmission, and Infection With Methicillin-Susceptible Staphylococcus aureus in a Neonatal Intensive Care Unit.

Project description: Not available

| S-EPMC8438598 | biostudies-literature