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Gene expression profiles of human adrenocortical NCI-H295R cells treated with cortisol biosynthesis inhibitors

ABSTRACT: We have recently identified a set of benzimidazolylurea derivatives including a representative compound (designated as CJ28), which inhibit both cortisol production and de novo cholesterol biosynthesis. To evaluate its putative mode-of-actions, we examined genome-wide RNA expression profiles of human adrenocortical carcinoma NCI-H295R cell cultures by treatment with CJ28 in comparison with metyrapone (MET), a well-established cortisol biosynthesis inhibitor.

ORGANISM(S): Homo sapiens

PROVIDER: GSE236435 | GEO | 2023/07/11

REPOSITORIES: GEO

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