Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Analysis of gene expression patterns tracking increasing metastatic potential of different clones from colon cancer CC36 primary culture

ABSTRACT: In order to find genes the expression of which follows the metastatic potential of different clonal cultures from the colon cancer heterogeneous CC36 primary culture. Each of the clonal culture has a different and defined metastatic potential as tested by transfilter assay.

ORGANISM(S): Homo sapiens

PROVIDER: GSE236690 | GEO | 2025/12/10

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Analysis of gene expression patterns tracking increasing metastatic potential of different clones from colon cancer CC14 primary culture

Project description:In order to find genes the expression of which follows the metastatic potential of different clonal cultures from the colon cancer heterogeneous CC14 primary culture. Each of the clonal culture has a different and defined metastatic potential as tested by transfilter assay.

2025-12-10 | GSE236688 | GEO

Analysis of gene expression patterns tracking increasing metastatic potential of different clones from colon cancer CC36 primary culture

Project description:Analysis of gene expression patterns tracking increasing metastatic potential of different clones from colon cancer CC36 primary culture

| PRJNA992058 | ENA

Analysis of gene expression patterns tracking increasing metastatic potential of different clones from colon cancer CC14 primary culture

Project description:Analysis of gene expression patterns tracking increasing metastatic potential of different clones from colon cancer CC14 primary culture

| PRJNA992057 | ENA

Transcriptome analysis of pancreatic cancer cell line that differ in metastatic potential

Project description:Two pancreatic cancer cell lines with different metastatic and growth potential were compared under hypoxic conditions and under normal atmospheric oxygen pressure. The FG cell lines shows very few metastases and slow growth in mouse xenograft models. L3.6pl, derived from FG by cycles re-implantation of metastatic cells obtained after orthotopic tumor growth in nude mice, shows high motility, aggressive growth and very high metastatic potential By comparison of the two cell lines under different oxygen concentration we tried to simulate in vivo conditions of tumors at different growth stages. Differentially expressed genes and transcription factor regulating coexpressed genes identified by SOTA clustering were used to identify key genes that define metastatic potential of pancreatic cancer cells Keywords: 2+2 factorial design 12 samples, two cell lines * two culture conditions(oxygen pressure) * three replicates

2010-09-30 | E-GEOD-9350 | biostudies-arrayexpress

Clonal Selection Drives Genetic Divergence of Metastatic Medulloblastoma

Project description:This SuperSeries is composed of the following subset Series: GSE34280: Clonal Selection Drives Genetic Divergence of Metastatic Medulloblastoma [Affymetrix SNP6 Arrays] GSE34355: Clonal Selection Drives Genetic Divergence of Metastatic Medulloblastoma [Illumina Infinium HumanMethylation27 Beadchip v1.2] Refer to individual Series

2011-12-13 | E-GEOD-34356 | biostudies-arrayexpress

Unique Leishmania mexicana clones secrete populations of extracellular vesicles with unique protein profile and variable infectious capability

Project description:The study of extracellular vesicles has become an incredibly important field of study, but the inherent heterogeneity of these vesicles continues to make their study challenging. The genetic variability and well-documented protocols for the growth and vesicle isolation from Leishmania parasites provide a unique opportunity to compare the heterogeneity of different populations secreted by Leishmania clones. Leishmania mexicana was cultured on solid SDM agar plates and 8 clonal colonies were selected. The EVs collected from the liquid cultures of these 8 clones were assessed by NTA, TEM, and proteomic analysis. We found that all 8 clonal L. mexicana cultures were visually indistinguishable from each other and had similar growth rate, and these physical similarities extended to their EVs. However, proteomic analysis reveals that the EVs collected have unique protein profiles compared to each other and EVs isolated from a heterogeneous liquid culture of L. mexicana. We selected 3 clonal EVs for further mouse infection experiments and found that EVs from CL7 L. mexicana consistently caused reduced footpad swelling in C57BL6 mice footpads compared to EVs from CL1, CL8, and heterogenous L. mexicana. This trend was not observed when infecting Balb/C mice with the parasites alone, with only CL1 L. mexicana causing significantly increased infection, nor in C57BL6 mice with all clonal L. mexicana parasites causing a similar infection. Our results together show that EVs isolated from different clonal colonies of L. mexicana have distinct differences in protein cargo which can lead to varying outcomes on Leishmania infection. Further evaluation will be needed to determine the underlying mechanisms behind this and verify that differences observed in infectivity are directly caused by variations between our L. mexicana clones, especially genetic sequencing and immunoblotting to validate our results.

2025-05-07 | PXD058429 | Pride

Metastatic potential in clonal melanomal cells is driven by a rare, early-invading subpopulation

Project description:Metastatic potential in clonal melanomal cells is driven by a rare, early-invading subpopulation

| PRJNA932436 | ENA

Gene expression analysis of metastatic and non-metastatic osteosarcoma cell lines

Project description:Analysis of two metastatic OS cell lines, KHOS and KRIB, and two non-metastatic OS cell lines, HOS and U2OS. Results show differences in gene expression between cell lines with different ability to metastasise in vivo. Each of the four cell lines were analyzed in tripicate. Total RNA was extracted from each triplicate cell line culture with Trizol. cRNA was amplified using the Ambion Illumina Total Prep RNA Amplification Kit. Concentration was determined in NanoDrop and qulity checked in the Agilent Bioanalyzer, before hybridizing to Illumina HT-12 BeadChip Array.

2013-07-19 | E-GEOD-49003 | biostudies-arrayexpress

RNA-seq of Highly Metastatic and Lowly Metastatic 4T1 Single Clones Treated with Iron Chelator Deferasirox (DFX)

Project description:Using bulk RNA-seq, the transcriptional profile of two cell lines with high or low metastatic properties derived from single clones of the murine 4T1 cell line treated or untreated with iron chelator DFX was analyzed in order to determine the mechanism underlying the inhibition preference of DFX for highly metastatic 4T1 cells.

2022-11-16 | GSE218133 | GEO

Transcriptome analysis of pancreatic cancer cell line that differ in metastatic potential

2010-09-30 | GSE9350 | GEO