Genomics

Dataset Information

41

Genome-wide analysis of novel splice variants induced by topoisomerase I poisoning shows preferential occurrence in genes encoding splicing factors


ABSTRACT: Topoisomerase I (Top1) relaxes both positive and negative supercoilings by producing transient Top1 cleavage complexes (Top1cc). Several studies have suggested the implication of Top1 in splicing. Here, we tested the implication of Top1cc in splicing at the global genome level in human carcinoma cells to determine whether Top1 inhibition selectively affects particular families of genes. Overall design: We tested the impact of Top1 inhibition on splicing at the genome-wide level in human colon carcinoma HCT116 cells. The RNA of HCT116 cells treated with camptothecin (CPT) for various times was analyzed with ExonHit Human Splice Array.

INSTRUMENT(S): ExonHit Human Genome Wide SpliceArray 1.0

ORGANISM(S): Homo Sapiens

SUBMITTER: Jennifer Barb  

PROVIDER: GSE23677 | GEO | 2011-07-22

SECONDARY ACCESSION(S): PRJNA130805

REPOSITORIES: GEO

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