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Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition [scRNA-seq]

ABSTRACT: We used single-cell RNA-sequencing (scRNA-seq) of melanocytes isolated from two distict red hair color (RHC) mouse models for comparison with and black hair color, functional MC1R signaling, to reveal a Pheomelanin Gene Signature (PGS) of differentially expressed genes in RHC melanocytes.

ORGANISM(S): Mus musculus

PROVIDER: GSE236918 | GEO | 2023/10/01

REPOSITORIES: GEO

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Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition

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