Too much of a good thing: Extended duration of gut microbiota depletion reverses protection from experimental autoimmune uveitis

ABSTRACT: Microbial sequencing revealed progressive reduction of gut microbiota that showed some differences in the two ABX groups compared to untreated controls. Interestingly, duration of ABX was associated with a gradual disappearance of the CD4+ and CD4+CD8+ subset of gut intraepithelial lymphocytes (IELs). This IEL subset is microbiota-dependent and is absent in germ-free mice. Relative abundance of Lactobacillus reuteri correlated with frequencies of CD4+CD8+ IELs and reduced EAU. Notably, IELs in culture suppressed antigen-specific activation of autoreactive T cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE236922 | GEO | 2023/11/17

REPOSITORIES: GEO