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Gene expression profiling of MDA-MB-231 cells incubated with therapy induced senescence secretome

ABSTRACT: TNBC, associated with poor prognosis and high tumour recurrence, are often treated with anti-mitotic drugs. However, cells may bypass treatment-induced cell death via mitotic slippage, resulting in multinucleated polyploid cells and senescence activation. Senescent cancer cells represent a population of residual disease and are highly secretory. The SASP elicited is enriched in soluble cytokines linked to tumor recurrence and distant metastasis. In contrast, sEVs derived from senescent cancer cells represent an underappreciated aspect of SASP and its mechanistic role in mediating paracrine effects remains poorly-understood. Here, we show senescent sEVs as a distinct population of SASP that could elicit anti-tumor activity.

ORGANISM(S): Homo sapiens

PROVIDER: GSE236953 | GEO | 2024/03/25

REPOSITORIES: GEO

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Gene expression profiling of MDA-MB-231 cells incubated with therapy induced senescence derived small extracellular vesicles

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NAD+ metabolism governs proinflammatory senescence secretome

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Evaluation of the secretome of senescent melanoma cells and the impact of silencing Mfn1 on the senescence-associated secretory phenotype (SASP) by shotgun proteomics analysis.

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Project description:Post-slippage cells increase expression of factors associated with SASP.

| PRJNA471655 | ENA