Enhancing glioblastoma radiotherapy by COMT inhibition

ABSTRACT: Next-generation sequencing (NGS)-derived transcriptomic profiling was carried out to compare the transcriptomic changes mediated by COMT knockout in U87 cells. We found significant enrichment of gene signatures involving IFNa/b signaling in COMT-KO U87 cells compared to control cells. Our analysis also demonstrated that COMT deficiency interferes with mitochondrial functions and induces the expression of genes associated with the anti-viral RNA sensing pathway.

ORGANISM(S): Homo sapiens

PROVIDER: GSE237053 | GEO | 2023/10/12

REPOSITORIES: GEO