FOXO-regulated Deaf1 controls muscle regeneration through autophagy

ABSTRACT: We performed RNAi screens to identify regulators of muscle regeneration. We identified Deaf1 and hypothesized that this transcription factor may regulate autophagy and in turn control myogenesis. We therefore performed chromatin-immunoprecipitation followed by next-generation sequencing (ChIP-seq) to identify Deaf1 downstream targets. The results suggest that Deaf1 binds to the promoters the multiple ATG genes, suppressing their transcription.

ORGANISM(S): Mus musculus

PROVIDER: GSE237088 | GEO | 2024/05/15

REPOSITORIES: GEO