Transcriptomics

Dataset Information

0

Single-cell comparison of day 7 vaccine, listeria and vaccinia virus elicited CD8 T cells


ABSTRACT: Protection from pathogens relies on both humoral (antibody-mediated) and cellular (T cell-mediated) responses. While infections robustly elicit both of these types of immunity, currently approved vaccine adjuvants largely fail to induce significant T cell responses. However, recent work by our lab and others suggests that the mechanisms governing vaccine-elicited T cells (Tvac) may be substantially different than those governing infection-elicited T cells (Tinf). We have recently demonstrated that optimal subunit vaccine-elicited T cell responses rely on different cytokine signals (IL-27 and 15) and metabolic function (oxidative phosphorylation vs. aerobic glycolysis) leading to phenotypically and functionally different outcomes (memory vs. effector). Our goal was to investigate the transcriptional programming that promotes Tvac formation. Using a single-cell RNA-seq approach, we compared Tvac and Tinf at day 7 post-immunization or infectious challenge to determine the heterogenity of CD8 T cell responses at this peak timepoint.

ORGANISM(S): Mus musculus

PROVIDER: GSE237416 | GEO | 2023/07/14

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2023-07-14 | GSE237415 | GEO
2023-05-15 | E-MTAB-12942 | biostudies-arrayexpress
2024-06-01 | GSE249806 | GEO
2013-01-09 | GSE43373 | GEO
2017-01-09 | GSE85339 | GEO
2024-07-01 | GSE264685 | GEO
2014-12-04 | E-GEOD-63825 | biostudies-arrayexpress
2021-04-12 | GSE165227 | GEO
2013-01-09 | E-GEOD-43373 | biostudies-arrayexpress
2024-10-14 | GSE279372 | GEO