Phage-Antibiotic Combinations Against Klebsiella pneumoniae

ABSTRACT: hvKP ATCC43816 and its lytic phage H5 were employed as a phage-antibiotic combination model. Based on the comprehensive characterization of phages, including cryo-electron microscopy, we evaluated the synergic effect of H5 on bacterial killing in vitro when combined with multiple antibiotics, and analyzed the advantages of phage-antibiotic combinations from an evolutionary perspective and proposes a novel PAS mechanism by using ceftazidime as an example.

ORGANISM(S): Klebsiella pneumoniae subsp. pneumoniae

PROVIDER: GSE237490 | GEO | 2023/09/14

REPOSITORIES: GEO