Transcriptomics

Dataset Information

0

Impaired glycosylation drives golgi stress-mediated gastric tumorigenesis that can be targeted by lectin-drug conjugates II


ABSTRACT: Downregulation or gene mutation of MUC6, a major component of gastric mucin, is often identified in human gastric cancers. However, the mechanistic role of MUC6 alteration in gastric carcinogenesis remains unclear. Here, using Muc6-deficient mice, we revealed that dysregulated glycosylation in Muc6-deficient gastric epithelium causes aberrant golgi stress responses, resulting in spontaneous gastric cancer development. Muc6-deficient tumor growth is dependent on MAPK activation, which is mediated by golgi stress-induced golph3 upregulation. Glycomic analysis and lectin-binding assays revealed abnormal expression of mannose-rich N-type glycans in Muc6-deficient gastric tumors. Banana lectin-drug conjugates, which bind to mannose-rich glycans, dramatically suppress mannose-rich murine and human gastric cancer growth. Thus, we propose golgi stress responses and aberrant sugar chains as promising therapeutic targets in gastric cancers accompanied with mucin expression disorder.

ORGANISM(S): Mus musculus

PROVIDER: GSE237689 | GEO | 2024/08/31

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2024-08-31 | GSE237822 | GEO
2024-08-31 | GSE237686 | GEO
2008-11-21 | GSE11944 | GEO
2018-01-31 | GSE64932 | GEO
2024-06-19 | GSE262875 | GEO
2011-06-14 | GSE29940 | GEO
2008-11-20 | E-GEOD-11944 | biostudies-arrayexpress
| PRJNA996161 | ENA
| PRJNA996883 | ENA
| PRJNA996164 | ENA