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Flexible and scalable control of T cell memory by a reversible epigenetic switch (sci-fate-seq)

ABSTRACT: In this study, we use a minimal ex vivo culture system to track CD8 T cell differentiation at the single cell and clonal lineage level during activation. To characterize early heterogeneity in memory and effector differentiation in this system, we subjected cells to temporally-resolved single-cell transcriptomic profiling using sci-fate-seq (Cao et al., Nature Biotech, 202).

ORGANISM(S): Mus musculus

PROVIDER: GSE237829 | GEO | 2023/07/25

REPOSITORIES: GEO

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