Project description:The genomic distribution of post-translationally modified histones in the zebrafish (Danio rerio) genome remain largely unraveled. The objective of this study was to (1) design a microarray covering all zebrafish gene promoters and 5' end of coding regions, and (ii) using these arrrays, map the genome-wide distribution of trimethylated H3K4 and H3K27 in the mbryo derived ZF4 cell line. Specifically, we determined teh enrichment profile of H3K4me3, H3K27me3 and of both (co-enriched) modifications in ZF4 cells. We determined average enrichment profiles through metagene analysis, functional terms enriched among genes marked by either modification, and pathway analysis. ChIP-chip experiments were performed from duplicate cultures

2011-02-08 | E-GEOD-23691 | biostudies-arrayexpress

Mapping of H3K4 and H3K27 trimethylation in zebrafish cells (Gene expression)

Project description:The genomic distribution of post-translationally modified histones in the zebrafish (Danio rerio) genome remain largely unraveled. The objective of this study was to (1) design a microarray covering all zebrafish gene promoters and 5' end of coding regions, and (ii) using these arrrays, map the genome-wide distribution of trimethylated H3K4 and H3K27 in the embryo derived ZF4 cell line. Specifically, we determined the enrichment profile of H3K4me3, H3K27me3 and of both (co-enriched) modifications in ZF4 cells. We determined average enrichment profiles through metagene analysis, functional terms enriched among genes marked by either modification, pathway analysis, and in relation to gene expression. Gene expression experiments were performed on three biological replicates.

2011-02-08 | E-GEOD-23679 | biostudies-arrayexpress

The association between gene expression and whole genome histone H3K4 mono-, di, and trimethylation

Project description:This SuperSeries is composed of the SubSeries listed below.

2010-12-07 | GSE11658 | GEO

Epigenetic repression via DNA methylation and trimethylation of H3K27 alters gene expression in esophageal adenocarcinoma

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-02-01 | GSE94545 | GEO

CXXC finger protein 1 is critical for T cell intrathymic development through regulating H3K4 trimethylation

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-04-14 | GSE79976 | GEO