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Effect of Valproic Acid on Endothelial Cells

ABSTRACT: Valproic acid (VPA) is a short-chain fatty acid used in the treatment of epilepsy and also considered to be an epigenetic modifier by functioning as a histone deacetylase (HDAC)-inhibitor. The aim of this study was to search for gene altered by VPA in human endothelial cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE23909 | GEO | 2012/03/14

SECONDARY ACCESSION(S): PRJNA130543

REPOSITORIES: GEO

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Transcription profiling by array of human umbilical vein endothelial cells treated with valproic acid

Project description:Valproic acid (VPA) is a short-chain fatty acid used in the treatment of epilepsy and also considered to be an epigenetic modifier by functioning as a histone deacetylase (HDAC)-inhibitor. The aim of this study was to search for gene altered by VPA in human endothelial cells. Human umbilical vein endothelial cells (HUVEC) from five individuals were cultured in the absence or presence of 4mM VPA for 24h. Cells were cultured in EGM-2 medium and all experiments were performed in passages 1 or 2.

2012-03-14 | E-GEOD-23909 | biostudies-arrayexpress

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Expression data from untreated and valproic acid (VPA) treated CD34+ Hematopoietic Stem Cells (HSCs)

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