Genomics

Dataset Information

40

Gene expression changes in neonatal and adult plasmacytoid dendritic cells (pDC) upon TLR7/8 stimulation


ABSTRACT: We want to define the differences in gene expression changes between neonatal and adult plasmacytoid dendritic cells upon stimulation with TLR7/8. These differences may point to specific signaling pathways which, in turn, may account for the known differential immune response of babies to vaccination or infection when compared to adults. Overall design: Total RNA obtained from MACS-purified human pDC (using Miltenyi's Diamond Plasmacytoid Cell Isolation Kit) stimulated with the synthetic TLR7/8 ligand 3M-003 for 1 or 6 hours in vitro compared to unstimulated pDC.

INSTRUMENT(S): Illumina human-6 v2.0 expression beadchip

SUBMITTER: Edgardo Fortuno III  

PROVIDER: GSE23932 | GEO | 2017-12-21

SECONDARY ACCESSION(S): PRJNA130425

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
GSE23932_RAW.tar Raw
GSE23932_non-normalized_pDC.txt.gz Txt
filelist.txt Txt
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