Targeting BMI-1 to deplete antibody-secreting cells in autoimmunity

ABSTRACT: We measured genes expression differences in antibody secreting cells from LynKO mice in following treatment with a BMI-1 inhibitor (PTC-028) or a vehicle control. BMI-1 inhibition lead to a reduction in antibody secreting cells in LynKO mice and in humans donors. We performed RNA sequencing to understand the impact of BMI-1 inhibition on antibody secreting cells in LynKO mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE239515 | GEO | 2023/10/05

REPOSITORIES: GEO